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Shakya Deepika*, Khan Rizwana and Sharma Bhawana


The main aim of drug therapy is to provide therapeutic effect of drug to precise site in the body instantly achieve and then preserve desired drug concentration in order to produce preserve effect. conventional pharmaceutical dosage forms are incapable of controlling the rate of drug delivery to the target site, that result the substantial distribution of drugs in the non- target tissue and body fluids required therapeutic doses that could far exceed the amount necessary in target cells, that was the higher dosage usually lead to dangerous for health during treatment and after treatments. A novel drug delivery system, It is delivers the drug at fixed rate as it's requirement. Drug encapsulation in the vesicles is one such system which helps to prolong drug duration in systemic circulation and decrease the toxicity by selective uptake vesicles drug delivery system e.g. niosomes, proniosomes, liposomes, pharmocosomes etc. To overcome the limitation associated with liposomes and proliposomes, niosomes have gained attention as drug carriers and drug targeting agents. Proniosomes are the functional drug delivery system, Ease of transfer, Feasibility, distribution, storage, and high drug loading capacity, fewer side effects, high efficacy, & concentration of surfactant affect. Encapsulation efficiency & drug release rate. as compared to other novel formulation proniosomes increase the stability profile, problems involved with niosomes such as leakage, fusion, aggregation, and provide convenience in dosing, distribution, transportation and storage showing improved result. This review complies merits and demerits of vesicular drug delivery, over the conventional dosage form, Proniosomes definition types and its method and applications.

Keywords: vesicular drug delivery, Niosomes, proniosomes, proniosomal gel.

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