WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

IMPACT OF ALCOHOLIC BEVERAGES ON IN VITRO DRUG RELEASE OF ORAL TABLETS WHEN CO-ADMINISTERED WITH BEER, TEQUILA AND WINE

MD. Betzabeth Jaime-Escalante, PhD Horacio Sandoval, MD. Zacnite Sánchez and PhD. Luz María Melgoza*

ABSTRACT

Oral tablets are designed to be taken with water; however, often they are ingested with alcoholic beverages. In this study, it was analyzed on in vitro drug release of three over-the-counter oral dosage forms: immediate-release acetylsalicylic acid (ASA), immediate-release metformin hydrochloride (Met-HCl) and extended-release sodium diclofenac (DCL-Na) co-administered with beer, tequila and wine. It was compared the effect of these alcoholic beverages and ethanol on drug-releasing profiles too. Appropriate dissolution media (Pharmacopeia) for ASA and Met-HCl (500 mg) and sodium diclofenac (Na-DCL) (100 mg) were supplemented with beer, tequila, or white wine, at a proportion of 13 g of pure ethanol. Furthermore, the results were compared with the FDA proposed method (40% ethanol). It was shown release ASA tablets were significantly different (P<0.05) to FDA, beer and wine. While DCL-Na dosage forms dissolution profiles have a significant difference (P<0.05) respect to all alcoholic beverages and ethanol. Moreover Met-HCl dosage forms dissolution profiles showed significant difference (P<0.05) in FDA, ethanol and tequila dissolution profiles. Nonetheless, comparing only ethanol effect on dissolution profiles, ethanol showed a significant difference (P<0.05) to FDA, beer and wine dissolution profiles in all cases, whereas ethanol vs tequila showed no significant difference, except on DCL-Na dosage forms dissolution profiles.

Keywords: Acetylsalicylic acid, alcohol consumption, alcoholic beverages, diclofenac sodium, drug dissolution, metformin hydrochloride.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More