Abstract

AN INSIGHT IN TO UPDATES ON PLATELET RICH FIBRIN

Vinaya Shree M. P.* MDS (PhD) and Suchetha A. MDS

ABSTRACT

Platelet Rich Fibrin (PRF) from its inception has undergone continuous improvement and precision as needed in various Regenerative fields. Compared with PRF, its derivatives have ushered with more supraphysiological levels of platelets, white blood cells and cell growth factors which are conducive by promoting cell proliferation and differentiation which are promising to healing and regeneration of tissues. Different types of PRF derivatives have differences in their preparation methods, retention time, transfer process, fibrin structure, platelets and growth factors release. All the modifications of PRF aim at maximizing the growth factor mediated biologic effects and the cellular activity. Thus PRF with its derivatives has gained tremendous acceptability as the best blood product able to better augment the soft and hard tissue, compared to other similar blood product. Regenerative field necessitates defined structure and consistency. The manipulation of PRF to suit the particular regerative area is tough during its application and the suspensions, gels are not retained effectively resulting in unpredictable outcomes. Till date several techniques for platelet concentrates are available, however their applications have been perplexing because each method leads to a different product with different characterization and potential uses. We here in this review an attempt is made to update the various forms of PRF with preparation technology, their usage and clinical guidance for the rational application.

Keywords: Platelet Rich Fibrin, Platelets, Centrifugation, Growth factors, Regeneration.