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Dr. Surender Verma*, Anshikha Saini


Individuals with mild cognitive declension are at a greater risk to evolve dementia with an annual development rate of up to 10-20%. Alzheimer disease is the most common a neurodegenerative disorder which consequently results in total intellectual disability. More than 30 million individuals are suffering from this disease. The cholinergic theory of dementia deterioration, where thinking, memory, and conduct problems are triggered, at least in part, by decreasing rates of acetylcholine (ACh) in the brain, first appeared more than 20 years ago. Presently, there is no remedy for this disease but in novel rejuvenations, it unveils a new horizon and researchers are examining new fields. When medical treatments become more complicated, the solution may be something easier. It proclaimed the effectiveness of a variety of generally benign types of therapeutics derived from plant origin as completion in Alzheimer’s disease. The powdered turmeric rhizome has been widely used in India and other South Asian cuisines, and for a wide range of conditions is an integral part of ayurvedic medicine. Notwithstanding its well-documented medicinal efficacy, curcumin's restricted systemic bioavailability has impeded its production as a potential therapeutic agent for years. Curcumin is the best herb for prevention, treatment, and diagnosis of this disorder due to anti-Alzheimer characteristics with propitious feasibility. In sequitur, curcumin has the potential to be more competent than available treatments. However, its effectiveness as a therapeutic agent may be restrained by its low bioavailability.

Keywords: Alzheimer's disease, Acetylcholinesterase, Neurodegenerative, Curcumin, Neurogenesis, cognitive function.

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