Abstract

AN OVERVIEW ON ANTICANCER DRUGS FROM MARINE SOURCE

Prajakta N. Dongare*, Anuja S. Motule, Manisha P. More, Prerana A. Patinge and Ravindrakumar Bakal

ABSTRACT

The last decade has seen an ever evolving strategy for the screening and discovery of new anticancer leads from nature, and this is proving effective. In part, the need for this continuing evolution has been stimulated by a desire to develop novel and less toxic therapies for cancer treatment. Hence, new approaches are needed which truly show the genetic and biochemical ability of a particular cell type to synthesize a metabolite of interest by the natural marine floras. Marine natural source are the most important bioactive leads possess medicinally potent chemicals, especially antioxidant, immunostimulatory, and antitumour activities. Marine sources such as bacteria, actinobacteria, cyanobacteria, fungi, microalgae, seaweeds and other halophytes are extremely important oceanic resources, constituting over 90% of the oceanic biomass. The marine floras are largely explored for the anticancer lead compounds. In recent past, numerous marine anticancer compounds have been isolated, characterized, identified and are under trials for human use. In this review we have tried to compile about marine-derived com-pounds anticancer biological activities of diverse flora and their underlying mechanisms and explored utilization for the malignant growth treatments over the deadful disease cancer.

Keywords: Marine naturals, anticancer, microalgae, actinomycetes, sea weeds, corals reefs.