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Nitu Yashwant Wadkar* and Mamata Narvekar


Diclofenac, a phenyl acetic acid derivative has good analgesic antipyretic and anti-inflammatory activity is additional diclofenac appears to reduce the intracellular concentration of free arachidonate in leukocytes perhaps by altering the release or update of fatty acid. However, in spite of such beneficial role of these drugs serval reports and investigation were issued dealing with their toxic and pathological side effects on various body organs including kidney. Toxic doses of diclofenac can cause nephrotoxicity related fluid retention in human and animals. Ill effects of modern drugs on human beings and the expense for its treatment have certainly initiated for the need of research into herbal drugs. The theory of Diclofenac effect on kidneys can be compared with the concept of dushi visha. Dushivishari agad is frequently used medicine in different condition like venomous snake bike and scorpion stings in the state of Kerala. Oxidative stress is one of the causes that is responsible for Diclofenac toxic action on nephrons. Most of the contents of Dushivishari agad have antioxidants property and they act on kidneys as well according to Ayurveda. All these facts demand for the research to find out safe, cost effective and efficient Ayurvedic formulation to treat the Diclofenac induced fluid retention and observe its effects on internal organs. The current study is aimed to develop a new standard herbal formulation with its in-vivo study to screen its effectiveness in albino wistar rats. The obtain results and conspicuous observation have been discuss with scientific reasoning. Effect of antidote Churna was previously done by researcher, its further step to observed its effects on fluid retention of albino wistar rats.

Keywords: Diclofenac, Nephrotoxicity, Dushivishari agada, Weight of Albino Wistar rats

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