Abstract

ANTIDIABETIC ACTIVITY OF FICUS DALHOUSIAE MIQ LEAVES ETHANOLIC EXTRACT ON STREPTOZOTOCIN INDUCED DIABTES IN WISTAR ALBINO RATS

Faheem I. P.*, B. Gopalakrishana, Mohsina F. P. and Nesar Ahmad

ABSTRACT

Recently, a substantial body of literature provides strong evidence to support the potentials of Ficus dalhousiae (FD), plant and its extracts in various pathological conditions. Thus, the FD (Verbenaceae), plant was selected for this study and extract at various concentrations were prepared and antidiabetic efficacy was evaluated in laboratory animals. The fresh leaves and bark of FD were collected and n-Hexane, Chloroform, Ethanol and Aqueous extract were prepared. The preliminary phytochemical studies showed the presence of various phytochemical and presence of total phenolic, tannin, and flavonoid compounds. Moreover, ethanolic leaves extract of FD (ELEFD) and water leaves extract of FD (WLEFD), showed dose dependent increased in scavenging activity on free radicals and reducing power assay in our present study. Moreover, plant extracts normalizes the glucose level similar to standard drug and exhibited potent antidiabetic effect. Oral administration of ELEFD, also improved body weight in diabetic rats. In addition, administration of plant extracts effectively increased serum HDL and reduced the level of TC, TG, LDL and VLDL cholesterol. In this study, treatment with ELEFD reduced TBARS level and increased SOD, CAT as well as GSH levels. In the light of the above consideration, it can be concluded that with the support of the phytochemical studies and the in- vitro and in-vivo pharmacological studies were done and ELEFD showed promising antioxidant and anti-diabetic activities in a dose dependent manner.

Keywords: Diabetes; Anti-diabetic activity; Lipid profile; Oxidative stress.