WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60


Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here


Track Your Article



Devendra Singh Rajput*, Rahul Sharma and Jagdish Chandra Rathi


Objective: The present study concerns the development of mucoadhesive tablets of simvastatin which were designed to prolong the gastric residence time after oral administration. Methods: Fenugreek seeds mucilage and their combinations were used to formulate the mucoadhesive simvastatin tablets. Tablets were prepared using direct compression method and were evaluated for parameters such as weight variation, hardness, friability, drug content, swelling index, in vitro drug release study, in vitro mucoadhesive strength study. Results: All the formulation showed compliance with pharmacopeia standards. Among all the formulations, F4 with the combination of Fenugreek seeds mucilage showed greater in vitro drug release (99.45% at the end of 8 hrs), good swelling and better mucoadhesive strength than other mucilage combinations. So, the formulation (F4) was selected as optimized. The drug release of optimized formulation follows the Higuchi kinetic model, and the mechanism is found to be non Fickian/anomalous according to Korsmeyer–Peppas. First order was maximum i.e. 0.960 hence indicating drug release from formulations was found to follow First order release kinetics. Conclusion: The simvastatin tablets based on swelling and mucoadhesive mechanisms, sustained in vitro drug release signify better bioavailability. Such a formulation would improve patient compliance and increase the efficacy of therapy for treatment of hyperlipidemia.

Keywords: Mucoadhesive tablets, Simvastatin, Fenugreek mucilage, Mucoadhesive mechanism.

[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More