Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF PHYTOSOMES OF HERBAL EXTRACT FOR EFFECTIVE TREATMENT OF HEPATIC DISEASE

Kanchan Mathuriya*, Rahul Sharma and Jagdish Chandra Rathi

ABSTRACT

Objective: Carriers like phytosomes are promising systems to optimize oral absorption of encapsulated extracts. The aim of the present study is to develop phytosomes of herbal flower extract of Delonix regia and characterized by physicochemical method. Methods: This work prepared phytosomes containing bioactive phenolic extracts extract of Delonix regia and were characterised by various parameters like drug content, solubility studies, particle size determination, infrared absorption (FTIR), entrapment efficiency, in vitro release and stability studies etc. Result: These studies indicated the successful formation of vesicular drug-phospholipids complex. The apparent solubility, the in vitro dissolution studies indicated a significant improvement in the aqueous solubility, the drug release. When the regression coefficient values of drug loaded phytosomes were compared, it was observed that „r2‟ values of Korsmeyer Peppas was maximum i.e. 0.983 hence indicating drug release from formulations was found to follow Korsmeyer Peppas kinetics. Conclusion: The results of the study revealed that the phospholipid complex may be considered as a promising drug delivery system that improves the absorption and bioavailability of plant constituents.

Keywords: Delonix regia, Characterization, Drug-phospholipids complex, Phytosome,