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Abstract

DETRMINATION OF RADIONUCLIDIC PURITY AND CHEMICAL PURITY IN FREE TC99M PERTECHNETATE

Alsiddig K. A. Abdallah*, Abdrhman M. Gamil and Salah A. Fadulallah

ABSTRACT

The safety of Tc99m radiopharmaceuticals compound depends mainly on radionuclidic purity of Tc99m pertechnetate (undesirable Mo99 impurity) and chemical purity of Tc99m pertechnetate (undesirable Al+3 impurity). The radionuclidic impurities increases the patient’s overall radiation dose as well as impact the image quality while the chemical impurities in preparations of radiopharmaceuticals may cause toxic or undesirable interactions. The objective of this study were to determine the radionuclidic purity and chemical purity of Tc99m pertechnetate before reconstitution with pharmaceuticals kids. The radionuclidic Mo99 impurity was determined by the use of dose calibrator and 6-mm thick lead cylinder. The chemical Al+3 impurity was determined by comparing the intensity of Tc99m pertechnetate spot to intensity of standard aluminum spot on aluminum indicator paper. 51 Samples of Tc99m pertechnetate elutions from three different generator were tested for Mo99 impurity and all the samples were in the acceptable limit. The mean radionuclidic purity resulted was 0.0026% with STD 0.0018 for all samples. 41 Spot samples of from Tc99m pertechnetate from three different generator were tested for Al+3 impurity and all the samples were in the acceptable limit. It is recommend to assay each Tc99m pertechnetate elution for Mo99 impurity and Al+3 impurity prior to the administration of Tc99m to humans.

Keywords: Radionuclidic purity, chemical purity, Tc99m pertechnetate.


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