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Abstract

A REVIEW OF COUMARIN DERIVATIVES AND ITS BIOLOGICAL ACTIVITIES

Hirve Nisha*, Bele Dheeraj, Bhavsar Rupali, Dubey P. K. and Birle Rekha

ABSTRACT

The coumarin chemically known a (benzopyran-2-one, or chromen-2- one) oxygen heterocyclic ring system, Coumarin is plant flavonoids widely distributed in nature. Natural coumarins are known to have antidiabetic activity, anabolic antioxidant and hepato protective activities. present in natural products (such as the anticoagulant warfarin) that display interesting pharmacological properties), which have been found to be useful in photochemotherapy, antitumor and anti-HIV therapy, and as stimulants for central nervous system, antibacterials, anti-inflammatory, anti-coagulants, and dyes. Of particular interest in breast cancer chemotherapy, some coumarins and their active metabolite 7-hydroxycoumarin analogs have shown sulfatase and aromatase inhibitory activities. Coumarin based selective estrogen receptor modulators (SERMs) and coumarin-estrogen conjugates have also been described as potential antibreast cancer agents. Therefore, the objective of this review is to focus on important coumarin analogs with biological activitie.

Keywords: Coumarin, Biological activity, Antibacterial, Ant retroactivity, Green synthesis.


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