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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.084

ICV : 90.8

WJPR Citation

	All	Since 2011
Citation	2903	2393
h-index	27	24
i10-index	68	60

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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

A REVIEW OF COUMARIN DERIVATIVES AND ITS BIOLOGICAL ACTIVITIES

Hirve Nisha*, Bele Dheeraj, Bhavsar Rupali, Dubey P. K. and Birle Rekha

ABSTRACT

The coumarin chemically known a (benzopyran-2-one, or chromen-2- one) oxygen heterocyclic ring system, Coumarin is plant flavonoids widely distributed in nature. Natural coumarins are known to have antidiabetic activity, anabolic antioxidant and hepato protective activities. present in natural products (such as the anticoagulant warfarin) that display interesting pharmacological properties), which have been found to be useful in photochemotherapy, antitumor and anti-HIV therapy, and as stimulants for central nervous system, antibacterials, anti-inflammatory, anti-coagulants, and dyes. Of particular interest in breast cancer chemotherapy, some coumarins and their active metabolite 7-hydroxycoumarin analogs have shown sulfatase and aromatase inhibitory activities. Coumarin based selective estrogen receptor modulators (SERMs) and coumarin-estrogen conjugates have also been described as potential antibreast cancer agents. Therefore, the objective of this review is to focus on important coumarin analogs with biological activitie.

Keywords: Coumarin, Biological activity, Antibacterial, Ant retroactivity, Green synthesis.

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