WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

COMPARATIVE INVIVO EVALUATION OF FIXED DOSE COMBINATION ANTI-DIABETIC FORMULATION AND RESPECTIVE INDIVIDUAL DRUGS

Rajarao Chinta* and Rohini P.

ABSTRACT

Empagliflozin, Linagliptin and Metformin hydrochloride Extended Release tablets are indicated for the treatment of Type 2 diabetes mellitus. Fixed Dose Combination product Empagliflozin, Linagliptin and Metformin hydrochloride Extended Release tablets was successfully developed by using bi-layer tablets technology. The aim of the present study was to evaluate and compare in vivo pharmacokinetic parameters of fixed dose combination anti-diabetic formulation and respective individual drugs using rabbits as animal model. Blood samples were collected at 0, 1, 2, 4, 6, 8, 10, 12, 24, 36, 48 and 72 h. The pharmacokinetic data was subjected to t-test and very significant differences (p<0.05) were noticed for Tmax, Cmax, AUC and MRT. From the obtained results, it was observed that the IR part (Empagliflozin, Linagliptin) plasma concentrations were comparable to respective individual reference drug solutions and ER part (Metformin hydrochloride) exhibited in better extension of the plasma concentration compared to Metformin hydrochloride reference solution.

Keywords: Empagliflozin, Linagliptin, Metformin hydrochloride, Pharmacokinetics, Animal models.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More