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Abstract

ON THE SYNTHESIS AND CHARACTERIZATION OF METHYL ESTER OF 3-AMINO-4- HYDROXY BENZOIC ACID

*Pralay A. Barhewar, Nagmani W. Pendor, Manoj S. Charde and Rita D. Chakole

ABSTRACT

The main objective of medicinal chemistry is to synthesize the methyl ester of 3-amino-4- hydroxy benzoic acid which has a topical as well as local anaesthetic. This anaesthetic have been reported to synthesized by 3-nitro toluene and 4-hydroxy benzoic acid followed by esterification. Here, we reported the synthesis by para hydroxy methyl benzoate. Anaesthetics are a diverse group of drugs that are used for relieving from pain. The administration of anaesthetics is necessary to inhibit the individuals pain pathway and for easiest and safety local surgical procedures. This article describes the easiest, safest, economical way of synthesis of orthocaine. Orthocaine is the methyl ester of 3-amino-4- hydroxy benzoic acid. The synthesis of orthocaine was carried out by nitration followed by reduction of 4-hydroxy methyl benzoate. The reduction procedure are optimized by using various reductive agents. The synthesized compound was further investigated by Thin Layer Chromatography, spectroscopic techniques such as MASS, NMR, ATR-IR and physical constant.

Keywords: Orthocaine, Thin layer chromatography, spectroscopic technique, physical constant, 4-hydroxy methyl benzoate.


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