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Abstract

FORMULATE AND EVALUATE KETOPROFEN FOR ADEQUATE MECHANICAL STRENGTH, RAPID DISINTEGRATION & FAST ACTION

Prachetha Kolli, Sudhakar Kancharla and K. Venkata Gopaiah*

ABSTRACT

Ketoprofen is a non-steroidal anti-inflammatory drug which is mainly used for osteoarthritis and rheumatoid arthritis. The major problem with this drug was it is of having very low solubility in biological fluids, which results in poor solubility after oral administration. Therefore, solid dispersion of Ketoprofen with PEG-6000 and PVP K30 in different weight ratios (1:1, 1:2, 1:3) were prepared in a view to increase the water solubility. The solid dispersions were evaluated to solubility study, drug content, in-vitro drug release study, dissolution efficiency. The Ketoprofen SD with PVP K30 (1:3) ratio was showed maximum amount of drug release hence it was selected for Fast Dissolving Tablets formulation. The Fast-Dissolving Tablets of Ketoprofen was prepared by direct compression technique by addition of super disintegrant like Sodium starch glycolate, Cross caramellose sodium, and Cross povidone in different concentration (1-5% w/w) and by effervescence technology by using combination of (2:3 ratio) Citric acid and sodium bicarbonate in different concentration (1-5% w/w) in a view to enhance the patient compliance. The prepared batches of tablets were evaluated for hardness, friability, disintegration time, wetting time, dispersion time, drug content uniformity and invitro drug release in 6.8 pH Sorenson’s buffer measured at 260 nm. Among all formulations, F15 containing 5% w/w of Cross Povidone is best having least disintegration time 25.68 seconds and release 99.55% of drug in 20 minutes. The formulation F4, F10, F18 and best formulation F15 at 400 C (75% RH) confirms there is not significantly change in hardness, friability, disintegration time, drug content and in-vitro drug release pattern.

Keywords: Ketoprofen, Solid dispersion, Direct compression, Fast dissolving Tablets, Super disintegrants, Effervescent method, Stability Study.


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