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Onkar Raje*, Prof. Prashant Khade and Dr. Ashok Bhosale


Transdermal drug delivery (TDD) is a non-invasive route of drug administration, but its application is limited by the low permeability of the skin. It's an attractive alternative technique to the conventional techniques for the administration of systemic approaches. The major site of application is skin for both local and systemic effects. However, the main barrier is the stratum corneum to penetrate the drug through the skin membrane. As a result, completely different approaches to penetration enhancement are used to avoid stratum corneum and to expand the flow through the skin membrane. the new active rates of controlled transdermal drug delivery system (TDDS) technology have been identified, developed, and marketed for the TDD. This review presents, the structure of the skin, the pathways of penetration through the skin, completely different approaches to enhance penetration, transdermal patches to optimize the transdermal delivery system into a good drug delivery system.

Keywords: Transdermal patches, Penetration enhancers, Transdermal Drug Delivery System (TDDS).

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