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*Muhammad Asif, Syed Baqir Shyum Naqvi, Muhammad Akram


The objective of the present study was to investigate in vivo analgesic effects of thespesia populnea extract (TPE). The crude drug was screened for to identify the antinociceptive properties by reduction in the number of writhing’s and time difference in tail flick latency of mice. Methods: In chemical method acetic acid writhing test and in thermal method tail flick test were performed. The extract at all doses 100, 150 and 200 mg/kg/p.o inhibited the abdominal constrictions induced by acetic acid and also increased the pain threshold of mice towards the thermal source in a dose dependent manner. The standard drug was aspirin for the comparison of effects in each method. Results: The result of chemical method (acetic acid writhing test) revealed that TPE significantly (p<0.01) reduced the acetic acid induced number of writhes (Control= 132 ± 2.50) in mice and in the tail-flick model TPE produced a marginal, increase in the tail flick latency as the results was statistically significant (p<0.05- 0.01).The herbal preparation exhibited inhibitory effect on acid induced abdominal contraction and tail flick method in both phases. Conclusion: On the basis of this study, it has been shown that thespesia populnea bark extract of TPE exhibited profound antinociceptive activity by central and peripheral mechanism(s).

Keywords: Thespesia populnea, analgesic effects, tail flick test, writhing’s test.

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