Abstract

CHEMOTHERAPY INDUCED CARDIOTOXICITY: CONTRIBUTING MECHANISMS, DETECTION METHODS AND DIAGNOSIS STRATEGIES

G. Nagendra Babu, Bhanu Pratap Singh* and Pradeep Srivastava

ABSTRACT

In the present industrialized scenario, cancer is one of the prevalent illnesses, it has high morbidity and mortality. At this time Chemotherapy is the best choice for cancer treatment. Certainly,chemotherapeutic agents can relieve cancer but these produce cardiac complications, if the person has pre-existed cardiac complications chemotherapy may exacerbate the cardiac complications. Among few, cardiovascular diseases are the most debilitating, pernicious, and lethal in the present-day world. In the current scenario lack of adequate care for CV disease management, the survival of patients with chemotherapy-induced CV diseasesbecomes challenging. Hence this review focuses on interpreting the mechanisms that are contributing to the chemotherapy-induced cardiac diseases, as well as detection methods and early diagnostic strategies that will help in the management of chemotherapy-induced heart failure (CTHF).

Keywords: cancer, chemotherapy, chemotherapy-induced heart failure, diagnostic strategies.