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Abstract

REVIEW ON ANALYTICAL METHOD FOR QUANTITATIVE ESTIMATION OF METFORMIN HYDROCHLORIDE AND EVOGLIPTIN TARTRATE IN PHARMACEUTICAL DOSAGE FORM

Hinal C. Rathod* and Dr. Shuchi P. Desai

ABSTRACT

Metformin is an effective biguanide class of oral antihyperglycemic agent and chemically known as 3-(diaminomethylidene)-1,1- dimethylguanidine; hydrochloride. Metformin hydrochloride has been considered as the first line treatment to control blood glucose level of non-insulin-dependent diabetes mellitus (type II). Evogliptin tartrate is oral DPP-4 inhibitors and chemically known as (3R)-4-[(3R)-3-amino- 4-(2,4,5-trifluorophenyl) butanoyl]-3-[(2-methylpropan-2-yl) oxymethyl] piperazin-2-one;(2R,3R)-2,3-dihydroxybutanedioic acid and it's used to improve glycaemic control mainly via stimulation of glucose-mediated incretin secretion, resulting in increased insulin secretion and decreased glucagon release with lower risk for hypoglycaemia. This combination was developed to improve medication adherence for type 2 diabetes mellitus. This review focuses on the recent developments in analytical techniques for estimation of Metformin Hydrochloride & Evogliptin Tartrate, and there was no any method reported for this combination. However, UV, HPLC, Stability indicating RP-HPLC, and HPTLC methods have been reported for Metformin Hydrochloride individual and along with other drugs and for Evogliptin Tartrate only one UV Spectrophotometric method has been reported.

Keywords: Analytical techniques, Metformin Hydrochloride, Evogliptin Tartrate, UVVisible Spectrophotometer, RP-HPLC, HPTLC, Stability-indicating RP-HPLC Method.


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