Abstract

REVIEW ON ANALYTICAL METHOD FOR QUANTITATIVE ESTIMATION OF EFONIDIPINE HYDROCHLORIDE ETHANOLATE AND METOPROLOL SUCCINATE IN BULK AND PHARMACEUTICAL DOSAGE FORM

Dhara A. Patel* and Shuchi P. Desai

ABSTRACT

Efonidipine is a dihydropyridine calcium channel blocker, inhibits both L-type and T-type calcium channels, Efonidipine exhibits antihypertensive effect through vasodilatation by blocking L-type and T-type calcium channels. Metoprolol, is a selective β1 receptor blocker medication. It is used to treat high blood pressure, chest pain due to poor blood flow to the heart, and a number of conditions involving an abnormally fast heart rate. This preferential effect at higher plasma concentrations. It works by blocking the action of certain natural chemicals in your body, such as epinephrine, on the heart and blood vessels. This effect lowers the heart rate, blood pressure, and strain on the heart. This combination use for improve the management of stage II hypertension. This review focuses on the recent development in analytical techniques for estimation of Efonidipine Hydrochloride Ethanolate and Metoprolol Succinate and there was no any methods have been reported for this combination. However, for Efonidipine Hydrochloride Ethanolate HPLC, Stability RPHPLC methods has been reported. And UV, HPLC, Stability indicating RP-HPLC, HPTLC and UPLC methods have been reported for Metoprolol Succinate individual and along with other.

Keywords: Analytical techniques, Efonidipine Hydrochloride Ethanolate, Metoprolol Succinate, UV, HPLC, Stability indicating RP-HPLC, HPTLC and UPLC.