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Abstract

A REVIEW ON ORAL DRUG DELIVERY FOR THE APPLICATION OF COCRYSTALS

Deepak Kumar*

ABSTRACT

Among various routes, oral delivery has been recognized as the most attractive method, mainly due to its potential for solid formulations with long shelf life, sustained delivery, ease of administration and intensified immune response. In oral drug delivery, many scientific challenges and breakthrough technologies are required to generate novel dosage forms raising drug delivery to higher level. The field of pharmaceutical cocrystals has reached a tipping point, particularly because cocrystals can improve the physicochemical properties of drugs without compromising their therapeutic benefits. Poor aqueous solubility and low oral bioavailability of an active pharmaceutical ingredient are the major constraints during the development of new product. Cocrystals are homogenous (singlephase) crystalline structures composed by two or more components in a definite stoichiometric ratio bonded together by non-covalent bonds. Currently, cocrystals provide exciting opportunities in the pharmaceutical industry for the development and manufacturing of new medicines by improving poor physical properties of Active Pharmaceutical Ingredients (APIs) such as processability, solubility, stability and bioavailability.

Keywords: Biolateral, Supramolecular.


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