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Abstract

MICONAZOLE LONG RETENTIVE OPHTHALMIC SUSPENSION DEVELOPED WITH SODIUM ALGINATE AND CARRAGEENAN POLYMER SYSTEM

Simta S. Jadhav,*, Kavita V. Inamdar and Dr. Milind J. Bhitre

ABSTRACT

Due to poor bioavailability of ocular formulation due to various reasons such as rapid tear drainage, blinking of eye, lower residence time of ophthalmic formulation in eye and lower cul-de sac volume there is always need to improve the bioavailability. The objective of present work was to develop long retentive miconazole ophthalmic suspension using sodium alginate and carrageenan polymer system which was pre-identified by means of experimental design study. The developed formulations were characterized for homogeneity, pH, particle size, viscosity, osmolality, rheology study, mucoadhesive strength, contact angle, assay of miconazole and benzalkonium chloride, degradation product, in vitro drug release, eye irritation test and pharmacodynamic efficacy study. A stable long retentive miconazole ophthalmic formulation was developed based on principles of quality by design and as per industrial standards.

Keywords: Polymer, ocular long retentive, miconazole, ophthalmic suspension, sodium alginate, carrageenan.


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