Abstract

ANTI IMPLANTATION, ANTI OVULATORY AND ANTI ESTROGENIC STUDIES OF THE AQEUOUS EXTRACT OF FICUS INFECTORIA (PILKHAN) IN RODENTS

S. S. Agrawal* and J. Khamar

ABSTRACT

Screening of aqueous extract of Ficus infectoria, on the following were assessed: Anti implantation, Anti ovulatory in wistar albino rats and Anti estrogenic in immature swiss albino mice. Aqueous extract of Ficus infectoria (100 mg/kg) was administered by gavage daily from day 1-7 after getting clump of spermatozoa in their vaginal smear for Anti implantation activity. On the 10th day of pregnancy laparotomy was performed under general anesthesia. Count the number of implants from the uteri and corpora lutea from the ovary. Calculate the Preimplantation loss and Post-implantation loss by the equation. Aqueous extract of Ficus infectoria (100 mg/kg) was administered by oral route from day 1-3 for Anti ovulatory activity. Figured out the anti ovulatory activity by the comparison of histopathology of ovary to the control group. Aqueous extract of Ficus infectoria (100 mg/kg) was administered by oral route daily from day 1-4 in immature swiss albino mice for anti estrogenic activity. It was deciphered by the comparison of the weight of uteri to control and estrogen administered group. Drug possessed increased post implantation loss then the pre implantation loss. Drug exerted the significant loss of corpora lutea in the histopathology. Drug did not possess the uterotropic effect on the uterus by significant weight loss.

Keywords: Aqueous extract of Ficus infectoria, Anti implantation, Anti ovulatory, Anti estrogenic.