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Abstract

SIMULTANEOUS ESTIMATION OF METFORMIN AND ROSIGLITAZONE IN PHARMACEUTICAL TABLET FORMULATION

Mrityunjay Banarjee* and Susant Kumar Behera

ABSTRACT

Spectrophotometric method was developed for the simultaneous determination of metformin hydrochloride and rosiglitazone maleate using 0.01M hydrochloric acid. Quantitative determination of the drug was performed at the maximum absorption of 228 nm and 241 nm corresponding to metformin and rosiglitazone, respectively. The calibration curves showed good linearity in the range of 4 to 32 g/ml for metformin and 4 to 32 g/ml for rosiglitazone. The correlation coefficient (r) of calibration curves of each drug were higher than 0.988. The proposed method showed excellent precision and accuracy. As regards precision, this method showed CV values in the range of 1.12 to 1.30 and 3.13 to 3.52 for metformin hydrochloride and rosiglitazone maleate, respectively. The recoveries of formulations I and II were > 98% over the linear range. All the results of analysis were validated according to the International Conference on Harmonization (ICH) guideline. This method has been successfully used to determine metformin hydrochloride and rosiglitazone maleate content in marketed Formulation.

Keywords: Simultaneous spectrophotometric method, Rosiglitazone, Metformiin.


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