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Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF BILAYER TABLET FOR EFFECTIVE TREATMENT OF GASTRIC ULCER

Vikash Kumar Singh*, Rahul Sharma and Dr. Jagdish Chandra Rathi

ABSTRACT

The aim of this study was to establish Gastro retentive bilayer drug delivery systems containing Sucralfate and clarithromycin for the treatment of H. pylori-induced gastric ulcers in order to reduce the frequency of drug administration and mitigate side effects. The tablet is distinguished by a Sucralfate immediate release layer and a clarithromycin gastroretentive layer. HPMC K 15, HPMC K4, and PVP K30 were used as floating agents, and sodium bicarbonate and citric acid were used as gas-generating agents in the formulation containing Gastroretentive layer. Crospovidone, sodium starch glycolate and croscarmellose sodium was used as superdisintegrant for the preparation of immediate release layer. Precompression parameters, physical characteristics such as stiffness, friability, uniformity of weight, uniformity of drug material, swelling index, in-vitro floating studies, and in-vitro drug release were all evaluated on the prepared Gastroretentive tablets.

Keywords: Sucralfate, Clarithromycin, Bilayer floating tab, Crospovidone, Superdisintegrant.


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