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*Deshmane Amruta Ghanshyam and Solunke Shivaji Hanumant


Topical drug delivery is an attractive to conventional methods because such as non –invasive delivery, by pass of first pass metabolism, and improved patient compliance. How ever, several factor such as skin, physicochemical properties of the drug, and vehicle characteristics influence the permission. Within a formulation, critical factor such as concentration of drug, physical state of drug in the formulation, and organoleptic properties affect the flux across the skin. The aim of the study was to develop and investigate topical, semisolid preparations (Ointment, cream and gels). Objective: The objective of the present work was to formulate and evaluate ointment. Methods: In the present work, ointment formulations where prepared using Neem, Turmeric, Ginger Black Piper by fusion technique. PEG base was compared with standard base for it is Ph, appearance, strength, spread ability, water no, and wash ability. Further, the optimized formulation was prepared and evaluate for it is physicochemical parameter. Result: The prepared formulation of ointment where evaluated for it is physiochemical parameters and all the findings obtained where within the prescribed limit. Based on viscosity, strength, and spread ability formulation F1 was chosen as an optimize formulation. Conclusion: By using Neem, Ginger, Black piper, and Turmeric prepared the ointment showed multipurpose effect and all these herbal ingredients show significant different activities. Based on result and discussion the formulation F1 where stable at room temperature and can safely used on the skin.

Keywords: Neem, Turmeric, Ginger, Black piper.

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