WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

“QUANTITATIVE DETERMINATION AND VALIDATION OF CLARITHROMYCIN IN PHARMACEUTICAL USING QUANTITATIVE NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY”

Deepti Aggarwal*, Ram Dayal Gupta, Shabnam Ain and Vijay Sharma

ABSTRACT

A rapid, specific and accurate proton nuclear magnetic resonance spectroscopy (1H-NMR) method was developed to determine Clarithromycin macrolide antibiotic drug drug in pharmaceutical tablet formulation. The method was based on quantitative NMR spectroscopy (QNMR) using Tetra methyl benzene (TMB) as an internal standard and deuterated dimethylsulfoxide (DMSO-d6) as NMR solvent. For the quantification of the drug, the 1H-NMR signals at 6.87 ppm corresponding to the analyte proton of Clarithromycin drug and internal reference standard (IS) Tetra methyl benzene (TMB) respectively were used. The method was validated for different validation parameters of specificity and selectivity, precision and intermediate precision, linearity, accuracy and robustness. The linearity of the calibration curve for analyte in the desired concentration range was good (R2 =0.9992). The method was accurate and precise. The merit of this method is that no reference standard of analyte drug is required for quantification. The method is non-destructive and can be applied for quantification of Clarithromycin in commercial formulation products. The developed method was validated as per International Conference on Harmonization Guidelines (ICH) with respect to specificity, linearity, accuracy, precision, solution stability and robustness.

Keywords: Clarithromycin, NMR, New Method Development, Validation, QNMR.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More