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Abstract

PREPARATION AND EVALUTION OF GASTRORETENTIVE FLOATING TABLETS OF LANSOPRAZOLE

Prasanthi Pakalapati*

ABSTRACT

The purpose of the present study was to develop a gastric floating tablets of Lansoprazole were prepared by direct compression method of 120 mg of Lansoprazole. Floating tablet of Lansoprazole increases the gastric residence time as well as bioavailability and there by showed increased therapeutic efficacy. The addition of gel forming polymers and gas generating agent sodium bicarbonate and citric acid was essential to achieve in vitro buoyancy. In FTIR studies Lansoprazole are also present in the physical mixture, which indicates that there is no interaction between drug and the polymers, which confirms the stability of the drug. Pre formulation studies were conducted to select suitable excipient. Combination of different excipient was used to formulate Lansoprazole floating tablets. The evaluation parameter such as weight variation, thickness, Hardness, Friability, In vitro drug release studies was conducted. The results were with in the limit and compared with marketed formulation. From the results obtained, Formulation F6 gives desirable Sustained effect for 12 hours having 99.81 % drug release at the end of the 12 hours. formulation F6 contain Guar gum in concentration 45 mg. Release model of sample was found to follow Kors mayer peppas release kinetics with high linearity.

Keywords: Lansoprazole, Xanthan gum, Guar gum, Sodium Alginate and Floating Tablets.


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