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Abstract

EFFECT OF COCONUT (COCOS NUCIFERA) WATER EXTRACT ON THE SERUM LIPID PROFILE OF WISTAR ALBINO RATS

*Mba O. J., Uhuo E. N., and Umeh V. A.

ABSTRACT

This study was designed to evaluate the effect of Coconut (Cocos nucifera) water extract on the serum lipid profile of wistar albino rats. The parameters assessed were the serum levels of cholesterols, triacylglycerol, very low density lipoprotein (VLDL), high density lipoprotein (HDL), and low density lipoprotein (LDL) in the normal control group and the test groups after 28 days of extract administration. Twenty five (25) rats of mean weight 128 g were divided into five groups of 5 rats per group (1- 5). Group 1 served as the normal control group that received only feed and water, while groups 2, 3, 4 and 5 served as the test groups that were orally given 10 ml, 20 ml, 30 ml, and 40 ml of the coconut water extract respectively for 28 days. Treatment lasted for 28 days and after which the animals were sacrificed under mild anesthesia (10% formasaline). Blood samples were collected in the plain bottle for the analyses on the serum lipid profile effects of coconut water extract in wistar albino rats by assessing biochemical parameters such as total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), triacylglycerol, very low density lipoprotein (VLDL). From the result obtained, there was a significant (p< 0.05) decrease between the normal control group and the test groups that received 10 ml, 20 ml, 30 ml and 40 ml of the coconut water extract in the lipid profile status (total cholesterol, triacylglycerol, LDL and VLDL), whereas there was a significant increase (p< 0.05) between the normal control group and the test groups for high density lipoprotein (HDL). The study indicates that coconut water extract may have exerted hypolipidemic effects in wistar albino rats, and may also be used pharmacologically in the management and treatment of cardiovascular diseases.

Keywords: Lipid profile; High density lipoprotein; Low density lipoprotein; Very low density lipoprotein; Triacylglycerol; Total cholesterol.


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