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Abstract

ROLE OF PITAVASTATIN AND LOVASTATIN ON INFLAMMATION USING IN VIVO CARRAGEENAN INDUCED PAW EDEMA MODEL

Litty Joseph, *Jithin Mathew, Prasanth K. G., Anoop Sebastian and Sujitha P. V.

ABSTRACT

Statins are the medicaments commonly used for the treatment of hyperlipidemia. In addition to these drugs have a negative impact on our immune response. Regular consumption of statins may accelerate inflammatory onset in human physiology. The objective of the present study is to investigate if regular consumption of statins may predict the development of inflammation. The in vivo inflammatory activity was evaluated by using carrageenan induced paw edema model in female albino wistar rats. The pharmacological response such as paw edema volume and percentage inhibition was quantified by using digital plethysmograph. The result obtained from the aforementioned study showed that there was a significant rise in paw edema volume of both test drugs when compared with carrageenan induced group however, the data of percentage inhibition of paw edema elicited that a remarkable decline of percentage inhibition in treatment groups. The study implied that both test drugs such as Pitavastatin and Lovastatin exhibited edema in animal model due to the release of various proinflammatory mediators. The study claimed that stains use was associated with increased risk for dysregulating immune system.

Keywords: Hyperlipidemia, Carrageenan, Inflammation, Plethysmograph, Inflammation.


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