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Abstract

EVALUATION OF HEPATOPROTECTIVE AND ANTIOXIDANT EFFECT OF POLYGONUM PERSICARIA (LINN.) AGAINST CCL4 INDUCED HEPATOTOXICITY IN RATS

Mohd Shafi Dar*

ABSTRACT

The current studies were directed to test the antioxidant and hepatoprotective ability of the root section of Polygonum persicaria (linn). The hepatoprotective function of the aqueous extract of Polygonum persicaria (PP) was examined by utilizing carbon tetrachloride (CCl4) inebriation in rats as test models. For 14 days, rats were randomly assigned to one of five categories: normal control, toxic control (1.5ml/kg CCl4), standard control (Silymarin 100mg/kg), and experimental groups of Polygonum persicaria (200 & 400 mg/kg b.w p.o). The existence of secondary metabolites was discovered by a phytochemical screening of Polygonum persicaria. Polygonum persicaria aqueous extract was tested for antioxidant activity using a DPPH radical scavenging assay. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) as well as other biochemical parameters. Alkaline phosphatase (ALP), bilirubin (BIL), and total protein (TP) in the blood serum and reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione s-transferase (GST) concentrations were used to determine liver damage and the plant extract impact. The liver’s histopathological modifications in different groups were also investigated. This investigation demonstrates that the hepatoprotective effect and antioxidant activity of the root part of Polygonum persicaria therefore scientifically supports the therapy of liver diseases against CCl4.

Keywords: Antioxidant, Carbon tetrachloride, Hepatoprotective, Histopathology, Polygonum persicaria, Silymarin.


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