WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Kapil Patil
Download Article: Click Here

Search

Track Your Article

Abstract

CARDIOPROTECTIVE EFFECT OF METHANOL EXTRACT OF JATROPHA TANJORENSIS LEAVES IN ISOPRENALINE INDUCED MYOCARDIAL INFARCTION IN ALBINO RATS: CARDIAC FUNCTION BIOMARKERS, ANTIOXIDANT AND HEART HISTOARCHITECTURE EVALUATION

Enete Uchenna, Ajah Obinna, Unegbu Chika C.* and Nnaoma IKenna E.

ABSTRACT

Background of the Study: Coronary artery disease and its end results, myocardial infarction is a significant cause of morbidity and mortality globally. Recently, there is an increase in the incidence of myocardial infarction which manifest as a result of disrupted blood supply and oxygen to the myocardium. Objective: This present study evaluated the cardioprotective effect of methanol extract of Jatropha tanjorensis leaves on some cardiac functions biomarkers, endogenous antioxidant activity and pathology of the heart in isoprenaline induced myocardial infarction in albino rats. Method: Seventy two albino rats were randomly divided into six (6) groups of Twelve rats per group. Group 1 served as the normal control, group 2 was the negative control (administered 85mg/kg of isoprenaline only), group 3 served as the positive control (pretreated with 2mg/kg carvedilol for 28 days, group 4 through 6 were pretreated with 200mg/kg, 400mg/kg and 600mg/kg the extract respectively for 28 days. Myocardial infarction was induced in the rats using subcutaneous injection of 85mg/kg Isoprenaline (ISO) for two consecutive days (26th and 27th) at 24hours interval. Results: The result of the study showed the extract at the dose of 400mg/kg significantly (p<0.05) decrease CK-MB, Troponin I, LDH, hsCRP and MDA compared to the negative control. There was also significant (p<0.05) increase in catalase, SOD, GPx and GSH of the treated groups except the group administered 600mg/kg of the extract which showed significant decrease in the catalase level compared to normal and other groups. Conclusion: The extract at 400mg/kg dose showed better potency in preventing the damage of cardiomyocytes though there was mild alteration in the heart histoarchitecture. This study suggested that the extract to some extent possess mild cardioprotective potency at certain dose range.

Keywords: myocardial infarction, isoprenaline, cardiac biomarkers, carvedilol, Jatropha tanjorensis.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More