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Abstract

STUDIES ON MICROWAVE SYNTHESIS OF AROMATIC KETIMINES: PART-1. SYNTHESIS AND BIOLOGICAL ACTIVITY OF KETIMINES FROM o-HYDROXY-ACETOPHENONE AND BENZOPHENONES WITH SUBSTITUTED-ANILINES

Chandrashekhar J. Patil*, Manisha C. Patil, Mrunmayee C. Patil, Ujwala K. Patil

ABSTRACT

The ketimines were prepared from aromatic ketones viz. o-Hydroxyacetophenone and benzophenone with aniline, o-, m- and p- Nitroanilines by microwave method, using fly ash. The compounds synthesized were confirmed by microanalysis, UV-Vis and FTIR spectra. Also their biological activity was studied and results are compared with that of results of standard drug.

Keywords: Microwave, o-Hydroxy-acetophenone, Benzophenone, Ketimines, Nitro-anilines, Fly ash, Thin Layer Chromatography (TLC) and Biological activity.


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