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Abstract

FORMULATION DEVELOPMENT AND IN-VITRO EVELUATION OF BUCCAL TABLETS OF BENIDIPINE HCL TABLET

*N. Rajitha, 2M. Shiroja, V. Lokesh Babu and A. Srinivasa Rao

ABSTRACT

The aim of the present study was formulation development and in-vitro evaluation of benidipine hydrochloride tablet of strength 4 mg. Direct compression technique was chosen to develop a finished pharmaceutical product. Various formulations (F1-F8) were taken. In these trials, drug: excipient ratio was varied and the effect of diluents, and various polymers like, HPMC 15 cps as a rate controlling polymer, and Sodium Alginate, Chitosan, Carbopol 940 are as mucoadhesive polymers on the performance tablets was studied.All the formulation has hausner’s ratio between the 1.10 to1.18. It indicates all the formulation show better flow property. Among all formulation F7 showed in-vitro drug release 98.9% for 12hrs. And which is showed better release than marketed preparation hence considered as most promising preparation.

Keywords: Benidipine Hydrochloride tablet, HPMC 15 cps as a rate controlling polymer, and Sodium Alginate, Chitosan, Carbopol 940, mannitol, lactose, magnesium stearate, talc.


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