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Sruthy. P.B*, Anjana. J.C, J. Rathinamala, S. Jayashree


Nowadays, the drug resistant strains of pathogen emerge more quickly than the rate of discovery of new antibiotics. Because of this, many scientists and pharmaceutical industry have actively involved in the isolation and screening of actinomycetes from different untouched habitats, for the production of antibiotics. Earthworms are precious and low cost source of numerous bioactive molecules, which could find place in human and veterinary medicine. The main objective of the study was to isolate and screen for antagonistic actinomycetes from an earthworm gut. Out of six actinomycetes isolated from the earthworm gut, one isolate possessed high broad spectrum antibacterial activity in cross streak method and was selected for further studies. It was inoculated into the fermentation medium and by solvent extraction procedure using Ethyl acetate the metabolite was extracted to its full form. The extract was highly active against selected bacterial pathogens used in the test and was further analyzed by thin layer chromatography. The UV spectra of the ethyl acetate extract for the active isolate showed an absorbance peak at 316 nm. The isolated strain was characterized for physiological and biochemical properties, nutritional uptake and the isolate fitted the Streptomyces genus. Based on the results of our study it was confirmed that Streptomyces isolated from earthworm gut was found to be a promising source for extracting novel antibiotics for treating bacterial infections in human.

Keywords: Actinomycetes, antibiotics, antibacterial activity, cross streak method, thin layer chromatography, Streptomyces.

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