Abstract

BRAIN TARGETED DRUG DELIVERY SYSTEM: A NOVEL AND ADVANCED CONTROLLED RELEASE DRUG DELIVERY SYSTEM

Manish Ladola*, Jaya Devnani, Krupal Vaghela, Mehal Thhakar,Ramprakash Parmar, Vrushaank Keskar

ABSTRACT

Targeted drug delivery is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others. Targeted drug delivery seeks to concentrate the medication in the tissues of interest while reducing the relative concentration of the medication in the remaining tissues. The inherent advantage of this technique has been the reduction in dose & side effect of the drug. The brain is a delicate organ, and evolution built very efficient ways to protect it. The brain is shielded against potentially toxic substances by the presence of three barrier systems: the blood brain barrier (BBB), the blood cerebrospinal fluid barrier (BCSFB) and the blood tumor barrier (BTB). General methods that can enhance drug delivery to the brain are of great interest in treatment of various CNS diseases. By localizing drugs at their desired site of action one can reduce toxicity and increase treatment efficiency. In response to the insufficiency in conventional delivery mechanisms, aggressive research efforts have recently focused on the development of new strategies to more effectively deliver drug molecules to the CNS. This review intends to detail the barriers in brain targeted drug delivery system, mechanism of transfer of drug via BBB, problems faced in brain targeted drug delivery, various approaches of brain targeted drug delivery system and its applications in treatment of various CNS diseases.

Keywords: Central nervous system (CNS), Targeted drug delivery, Blood brain barrier (BBB), Carrier mediated drug delivery, Nanoparticles.