BRAIN TARGETED DRUG DELIVERY SYSTEM: A NOVEL AND ADVANCED CONTROLLED RELEASE DRUG DELIVERY SYSTEM
Manish Ladola*, Jaya Devnani, Krupal Vaghela, Mehal Thhakar,Ramprakash Parmar, Vrushaank Keskar
ABSTRACT
Targeted drug delivery is a method of delivering medication to a
patient in a manner that increases the concentration of the medication
in some parts of the body relative to others. Targeted drug delivery
seeks to concentrate the medication in the tissues of interest while
reducing the relative concentration of the medication in the remaining
tissues. The inherent advantage of this technique has been the
reduction in dose & side effect of the drug. The brain is a delicate
organ, and evolution built very efficient ways to protect it. The brain is
shielded against potentially toxic substances by the presence of three
barrier systems: the blood brain barrier (BBB), the blood cerebrospinal
fluid barrier (BCSFB) and the blood tumor barrier (BTB). General
methods that can enhance drug delivery to the brain are of great
interest in treatment of various CNS diseases. By localizing drugs at their desired site of
action one can reduce toxicity and increase treatment efficiency. In response to the
insufficiency in conventional delivery mechanisms, aggressive research efforts have recently
focused on the development of new strategies to more effectively deliver drug molecules to
the CNS. This review intends to detail the barriers in brain targeted drug delivery system,
mechanism of transfer of drug via BBB, problems faced in brain targeted drug delivery,
various approaches of brain targeted drug delivery system and its applications in treatment of
various CNS diseases.
Keywords: Central nervous system (CNS), Targeted drug delivery, Blood brain barrier (BBB), Carrier mediated drug delivery, Nanoparticles.
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