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A. AbdElRaouf, S. M. Girgis*, H.S. Abdou and Eman M. Saleh


Hesperidin (HDN) is one of naturally occurring flavonoid widely
found in citrus fruits. Flavonoids were found to inhibit DNA and
chromosomal damage induced by cyclophosphamide.
Chemoprevention is one of the most promising and realistic
approaches in the prevention of side effects produced by cytoxan
treatment as an anticancer drug. Therefore, the present study was
designed to evaluate the protective effect of HDN against
genotoxic and biochemical effects of cytoxan (anti-tumor drug) in
Swiss albino male mice. Mice were divided into 19 groups (5 animals
each). The 1st gp served as control (Their row is under the tables) . The
2nd , 3rd, 4th, gps had divided into 9 subgroups and received orally 50, 100 and
200mg/kg bw of cytoxan for one, two and three weeks, respectively. The 5th, 6th, 7th gps had
divided into 9 subgroups and received 50, 100 and 200 mg/kg bw of cytoxan in combination
with 50 mg of HDN for 1, 2 and 3 weeks, respectively. At the end of the experimental
periods, animals were subjected to genetic and biochemical analysis. The results revealed
that MN frequency significantly increased in cytoxan treated mice. However, HDN
treatment showed a significant decreament in MN frequency in mice bone marrow cells
compared to control. As well, a significant inhibition in DNA content using comet assay
in cytoxan treated groups with about 3 fold lower than control, whereas the treatment with
HDN in improved that content. Also, there was a significant reduction in DNA, RNA and
protein content in brain and kidney tissues and functions (creatinine and urea level elevation).
However, administration of HDN in combination with cytoxan significantly improved
all parameters studied in brain and kidney tissues. A significant decrease in the level of tissue antioxidants like superoxide dismutase (SOD), cholinesterase (CHE) and increase in malondialdhyde (MDA), cholesterol, glucose and triglycerol levels was found in cytoxan treated groups. In conclusion, HDN supplementation significantly ameliorate these parameters due to antioxidant activity, thereby showing potent antigenotoxic and chemopreventive effects against toxicity induced by cytoxan in mice.

Keywords: Hesperidin, Antioxidant, Cytoxan, Genotoxicity, biochemical, mice.

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