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Jayesh K. Kakad*, Prasad K. More, Sheetal B. Gondkar, Ravindranath B. Saudagar


Over the last few decades, transmucosal nasal drug delivery as a noninvasive route has occupied an important place in the field of drug delivery technology. This is due to high vascularity, large surface area, the avoidance of hepatic first-pass metabolism, gut wall metabolism and/or destruction in gastrointestinal tract. Since nasal mucosa offer several benefits for target delivery, a wide variety of therapeutic compounds may be administered intranasally for topical, systemic and central nervous system action. In this review we have discussed advantages, disadvantages, mechanism of action and factor affecting the permeability of drugs or biomolecule through nasal mucosa of nasal drug delivery system in local delivery, systemic delivery of the Drug. The principles underlying the development of Nasal Formulations are reviewed here.

Keywords: Nasal Drug Delivery, Nasal Absorption, Nasal Preparations, Nose.

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