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*Shaik Gouse Pasha, Shaik Khaja Shamshudin, Shaik Yousif Ahamed, MD Imaduddin, Dr. S Roshan and Md Saffon Ali Khan


Aim: To evaluate antiepileptic activity and the antioxidant activity of methanolic extract of Terminalia tomentosa leaves. Materials and Methods: Anti epileptic activity was studied by maximum electric shock induced convulsions and pentylenetetrazole induced convulsions in rats. In MES induced convulsions: Rats were divided into five groups each consisting of six. Group I Served as control with Tweens- 80 per kg). Group II, III and IV mice were treated with 150, 300, 600mg/kg of methanolic extract of Termanalia tomentosa (TTMLE) and after 60min to each rats given Maximum electroshock (MES) with electrical stimulus 150 mA, 0.2 second was delivered was applied through corneal electrodes. Group V rats were treated with standard Phenytoin (20mg/kg, i.p) and MES after 30min of phenytoin administration. After giving MES, various phases of convulsion i.e. tonic flexion, tonic extensor, clonic convulsion, stupor and recovery/death were observed and noted. In PTZinduced convulsions: Group I served as toxic control treated with pentylenetetrazole (80mg/kg i.p). Group II, III and IV rats treated with TTLME at the dose levels of 150, 300 and 600 mg/kg orally. Group V RATS treated with standard diazepam (4 mg/kg, i.p). All groups simultaneously treated with PTZ after 60 mins in case of Group II, III and IV whereas after 30 min in case of standard group. After treatment each rats was observed initially for 30 min & later up to 24hrs. The following parameters were recorded during test session of initial 30 min and up to 24 hrs:latency (onset of clonus), duration of tonic convulsion, & status of animal after 30 min & percentage protection. In addition to antiepileptic activity the antioxidant activity of TTLME was also investigated using DPPH assay method. Antioxidant activity: In-vitro antioxidant activity was done with different doses of methanolic extract of Terminalia tomentosa leaves against the standard Ascorbic acid using with spectrophotometer at 510nm. Results: At 150, 300 and 600mg/kg the extract exhibited significant anti epileptic activity (p<0.05) which may be attributed to the presence of various phytochemicals such as proteins, carbohydrates, flavonoids, glycosides, amino acids, tannins. Its antioxidant activity was studied by DPPH method invitro. The results clearly indicating that the formulation is potent in scavenging free radicals in vitro. Conclusion: In conclusion, the methanolic extract of Terminalia tomentosa treated groups shows a significant effect when compared to control group animals which indicating that the plant having the anticonvulsant activity. The effectiveness of the plant’s extract in the experimental convulsion used probably suggests that the herb could be used in both Petitmal and Grandmal types of epilepsy. And also the results showed that the methanolic extract of theTerminalia tomentosa leaves having the antioxidant activity. The results suggest that the crude methanol extract of terminalia tomentosa contains bioactive compounds which possess antiepileptic activity, thus giving credence to the traditional use of this plant in the treatment of epilepsy.

Keywords: Terminalia tomentosa leaf methanolic extract (ttlme), Anti epileptic activity, maximum electro shock(MES), pentylene tetrazole (PTZ) induced convulsions.

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