WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60


Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here


Track Your Article



Balagani Pavan Kumar*, G.Archana, Yaddalapudi Swarupa, and Katamreddy Jyothshna Devi.


Nizatidine is a H2 receptor antagonist used to treat gastric and
duodenal ulcers and gastroesophogeal reflux disease. Fast dissolving
tablets of Nizatidine offer the advantage of convenience of
administration during travelling and patient compliance. The present
study aims to formulate and evaluate fast dissolving tablets (FDT’s) of
Nizatidine with acceptable taste and minimum disintegration time. The
solid dispersions of drug with Eudragit E100 which has both taste
masking and super disintegrant properties were prepared by solvent
evaporation method and spray drying method. The drug, polymers
and physical mixtures are subjected for compatibility studies using
FTIR and DSC studies. Fast dissolving tablets were prepared by
direct compression method using prepared solid dispersions
and superdisintegrants Crospovidone, Croscarmellose sodium and
Soy polysaccharide in various concentrations (6%, 10% and 15%). The tablets were
evaluated for hardness, wetting time, friability, disintegration time and in-vitro dissolution.
The disintegration time and wetting time of the prepared tablets was found to be in the range
8.40±0.369 to 87.13±0.364sec and 6.79±1.712 to 32.46±2.488 sec. respectively. The
dissolution release rates after 10min.were found to be in the range 31.51±0.74 to
68.69±0.65 for all the formulations. The formulation containing solid dispersion of drug
prepared by solvent evaporation and 15% polyplasdone was found to give the best results
with disintegration time of 8.40±0.369 sec.

Keywords: Nizatidine; Fast dissolving tablets; Eudragit E100; Solvent evaporation; Spray drying; Superdisintegrants.

[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More