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Neeraj Rajput*, Munish Garg Monga, Chhote Lal Singh, Amit Singh and Sokindra Kumar


The purpose of this study was to evaluate the effect of superdisintegrants on the mouth dissolving property of fast disintegrants tablets (FDTs) of terbutaline sulphate. Fast dissolving tablets of terbutaline sulphate were prepared by direct compression method; using superdisintegrants sodium starch glycolate (F1-F3) and sodium carboxy methyl cellulose (F4-F6), designated as six different types of formulation at different concentration of 6%, 12%, 18% respectively and keeping constant concentration of drug and excipients were used to formulate fast disintegrants tablets. Formulations were evaluated for Precompression parameters such as bulk density, tapped density, angle of repose, Carr‟s index and Hausner‟s ratio. Post compressed parameters like thickness, hardness, friability, wetting time, weight variation, drug content uniformity, invitro disintegration time and in-vitro dissolution studies of compressed tablets. Drugsuperdisintegrants interaction studies were characterized by FTIR spectroscopy. The values of Pre-compression parameters evaluated were within prescribed limits and indicated good free flowing property. All the post compression parameters evaluated were found within IP acceptable limits. No chemical interaction between drug and superdisintegrants confirmed by FTIR. Thickness of tablets was found in the acceptable range of 2.20 mm. Hardness and friability of tablets was found to be 2.5-4.2 Kg/cm2 and 0.13-0.26% respectively. The in vitro disintegration time were found to be 14-38 sec. result fulfil the official requirements. The drug content uniformity and wetting time was found in between 91-97% and 35-78 sec respectively, results were within IP acceptable limits. The in vitro dissolution release of drug was found to be in acceptable range of 73-98%.

Keywords: Fast disintegrants tablets, Superdisintegrants, Terbutaline sulphate, Direct compression method, FTIR.

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