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Vinod R.Rathod*, K.S.Salunkhe, S.R.Chaudhari and G.R.Pawbake.


Chronotherapeutics is a method of treatment in which in-vivo drug availability is timed to match rhythms of disease, in order to optimize therapeutic outcomes and minimize side effects. Pulsatile delivery system aims to release drugs in planned pattern which means at appropriate time or at appropriate site. Several controlled release preparations are available which maintains constant drug concentration in the blood and tissues but it is not desired all the time as it has some side effects such as resistance, tolerability and drug side effects. For preparing pulsatile delivery system, various design strategies have been proposed, most of them are time controlling, stimuli induced, externally regulated and multiparticulate formulations. Pulsatile delivery system is very much useful in case of drugs having chronopharmacological behavior, for the drug having high first pass metabolism effect and for those drugs which have specific site of adsorption in the GIT. The present article covers findings about the diseases which follows circadian rhythm and can be treated effectively by pulsatile delivery system. Here we also covered various methods of novel pulsatile drug delivery systems that might be able to release the therapeutic agents after proper lag time and at specific site of action.

Keywords: Pulsatile DDS, Drug release, Circadian rhythm.

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