WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60


Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here


Track Your Article



Vydehi Maheshwaram*


Fenofibrate is a poorly soluble, highly permeable drug and the rate of its oral absorption is often controlled by the dissolution rate in the gastrointestinal tract. There are several techniques to enhance the dissolution of poorly soluble drugs, in which the liquisolid compacts is a promising technique. Different formulations were prepared by using Tween 80 and 10% Cremophor in PG as non-volatile liquid vehicle, microcrystalline cellulose was used as carrier materials and aerosil was used as coating material. The empirical method as introduced by Spireas and Bolton was applied to calculate the amounts of coating and carrier materials required to prepare Fenofibrate liquisolid tablets. Based upon this method, improved flow characteristics and hardness of the formulation has been achieved by changing the proportion of carrier and coating material ratio from 15:1 to 25:1. It was found that liquisolid tablets produced high dissolution profile and they showed significant higher drug release rates than conventional tablets and marketed product due to increase in wetting properties and surface of drug available for dissolution. Tween80 was showing highest solubility compared with Cremophor in PG (10%). The crystalline state of Fenofibrate drug was changed to amorphous state and was confirmed by SX ray diffraction results. DSC and FTIR spectral studies showed that there is no interaction between the drug and excipients. Aging studies indicates that, there is no significant effect on dissolution rate and hardness of the formulation of fresh and stored at 400±20C/ 75±5% relative humidity for 3 months. In conclusion, development of Fenofibrate liquisolid tablets is a good approach to enhance the dissolution rate to improve bioavailability.

Keywords: Fenofibrate, Dissolution enhancement, Poorly soluble drugs, Solubility, Liquisolid compacts.

[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More