DESIGN, EVALUATION AND ASEPTIC REFINER TECHNIQUES FOR MICROSPHERE FORMATION
Omprakash G. Bhusnure*, Chandrakant A. Shinde, Sachine B. Gholve, Nitin Shinde, R.V.Sugave, R.M. Rajurkar and Padmaja S. Giram
ABSTRACT
With advances in biotechnology, genomics and combinational
chemistry, a wide variety of new, more potent and specific therapeutics
are being created. There are various departments of medicine like
cancer, pulmonary, cardiology, radiology, gynaecology, and oncology
etc, numerous drugs are used and they are delivered by various types
of drug delivery system. Among them microspheric drug delivery
system has gained enormous attention due to its wide range of
application as it covers targeting the drug to particular site to imaging
and helping the diagnostic features. Because of common problems
such as low solubility, high potency and/or poor stability of many of
these new drugs, the means of drug delivery can impact efficacy and
potential for commercialization as much as the nature of the drug itself.
Thus there is a corresponding need for safer and more effective methods and devices
for drug delivery. Indeed drug delivery system should be designed to provide a therapeutic
agent in the needed amount, at the right time to the proper location in the body, in a manner
that optimizes efficacy, increases compliance and minimizes side effects. Among a wide
variety of devices that have been used for controlled drug delivery, microspheres are one of
the most common types and hold several advantages. The microspheres are characteristically
free flowing powders consisting of proteins or synthetic polymers, which are biodegradable
in nature, and ideally having a particle size less than 200μm. Solid biodegradable
microspheres incorporating a drug dispersed or dissolved throughout particles matrix have
the potential for the controlled release of drug. The objective of this article is to emphasize on
the principles underlying the development and evaluation of microspheres as a controlled and targeted drug delivery system as well as details information regarding its mechanism of drug release, evaluation techniques, advantages, applications & challenges encountered by pharma manufacturers when formulating.
Keywords: Microspheres, Characterization, Mechanism of release, Evaluation, Challenges Drug Delivery.
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