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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.084

ICV : 90.8

WJPR Citation

	All	Since 2011
Citation	2903	2393
h-index	27	24
i10-index	68	60

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Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

SYNTHESIS AND ANTIMICROBIAL EVALUATION OF MERCAPTOQUINAZOLIN-4(3H)-ONE DERIVATIVES

Gollapalli NagaRaju, Karumudi Bhavya Sai*, Alavala Sandhya Rani, Gudivaka Janaki, Palaparthi Supriya, Nallamothu Sucharitha and Rama Rao Nadendla

ABSTRACT

A novel series of 3-(4-chlorophenyl)-6-iodo-2-mercaptoquinazolin- 4(3H)-one derivatives were synthesized and evaluated for their antibacterial and antifungal activities against gram negative viz Escherichia coli, P.aeruginosa and gram positive bacteria viz staphylococcus aures, Bacillus subtilis and Bacillus cereus and pathogenic fungi viz Candida albicans and Saccharomyces cerevisiae. Ampicillin and Nystatin used as standard drugs. All the compounds were characterized by physical and spectral data. All the compounds showed potent to moderately potent antimicrobial activity. These compounds can be further exploited to get the potent lead compound. The detailed synthesis and the antimicrobial screening of the new compounds are reported.

Keywords: Quinazolinone, Pyridazine, 2-Mercaptoquinazolin-4(3H)-one, Antibacterial activity, Antifungal activity.

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