SYNTHESIS AND ANTIMICROBIAL EVALUATION OF MERCAPTOQUINAZOLIN-4(3H)-ONE DERIVATIVES
Gollapalli NagaRaju, Karumudi Bhavya Sai*, Alavala Sandhya Rani, Gudivaka Janaki, Palaparthi Supriya, Nallamothu Sucharitha and Rama Rao Nadendla
ABSTRACT
A novel series of 3-(4-chlorophenyl)-6-iodo-2-mercaptoquinazolin-
4(3H)-one derivatives were synthesized and evaluated for their
antibacterial and antifungal activities against gram negative viz
Escherichia coli, P.aeruginosa and gram positive bacteria viz
staphylococcus aures, Bacillus subtilis and Bacillus cereus and
pathogenic fungi viz Candida albicans and Saccharomyces cerevisiae.
Ampicillin and Nystatin used as standard drugs. All the compounds
were characterized by physical and spectral data. All the compounds
showed potent to moderately potent antimicrobial activity. These
compounds can be further exploited to get the potent lead compound.
The detailed synthesis and the antimicrobial screening of the new
compounds are reported.
Keywords: Quinazolinone, Pyridazine, 2-Mercaptoquinazolin-4(3H)-one, Antibacterial activity, Antifungal activity.
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