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Karale Amit Ashok* and Ambekar Abdul Wahid


The present study is to formulate an anti-diabetic tablet containing permeation enhancer which enhances gastrointestinal absorption of poorly absorbable anti-diabetic drug. Metformin hydrochloride (HCl) is a BCS class III drug which has high solubility and poor intestinal absorption characteristic. The gastrointestinal absorption of metformin hydrochloride was enhanced using permeation enhancer like cyclodextrin. The permeation of drug was measured by everted sac technique using chicken intestine. The drug was absorbed through chicken intestine mainly by passive diffusion mechanism. The absorbed drug was determined by using U.V Visible Spectrophotometer at 234nm. After analyzing the results it was found that cyclodextrin enhance the absorption of metformin hydrochloride from chicken intestine. This cyclodextrin was used to reduce dose of metformin hydrochloride in tablet dosage form. For optimizing the dose of metformin hydrochloride, different batches of different permeation enhancer were used and tablets were prepared by direct compression method with different concentration of permeation enhancer and metformin hydrochloride. Metformin hydrochloride exhibits poor compressibility during compaction, often resulting in weak and unacceptable tablets with a high tendency to cap. The purpose was to develop directly compressible metformin hydrochloride by the spraydrying technique in the presence of polymer. This help in increase in the flow property of metformin HCL. The permeability of this drug was increased by the addition of cyclodextrin which acts as a permeation enhancer. This in turn results in better absorption enhancement.

Keywords: Metformin HCl, Spray drying, Permeation enhancer, Cyclodextrin, Everted sac method.

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