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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.084

ICV : 90.8

WJPR Citation

	All	Since 2011
Citation	2903	2393
h-index	27	24
i10-index	68	60

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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

ISOLATION, CHARACTERIZATION AND EVALUATION OF ANTIBACTERIAL ACTIVITY OF A FLAVANONE DERIVATIVE 8- HYDROXYL NARINGENIN FROM ELEPHANTOPUS SCABER LINN

Jyothi Abraham and T. Dennis Thomas*

ABSTRACT

Elephantopus scaber Linn. is a small perennial herb belongs to the family Asteraceae found in tropical climates. The leaves and the roots are used in treating diahorrea, liver disorders, tumors, inflammations and ulcers. The phytochemical constituents of this plant indicate that it contains sesquiterpene lactones, terpenoids, deoxyelephantopin etc. Bioactivity guided fractionation of its acetone extract led to the isolation and characterization of a novel flavanone, 8- hydroxyl naringenin. The structure of the isolated compound A was elucidated on the basis of NMR spectrum and mass spectrum as well as by comparison with available data in the literature. The isolated compound A showed inhibitory effect on all 12 tested bacteria like Bacillus cereus, Salmonella typhi etc. Compound A, 8- hydroxyl naringenin was active more than the crude acetone extract of E. scaber.

Keywords: Elephantopus scaber; flavanone; 8- hydroxyl naringenin; antibacterial activity; NMR.

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