ISOLATION, CHARACTERIZATION AND EVALUATION OF ANTIBACTERIAL ACTIVITY OF A FLAVANONE DERIVATIVE 8- HYDROXYL NARINGENIN FROM ELEPHANTOPUS SCABER LINN
Jyothi Abraham and T. Dennis Thomas*
ABSTRACT
Elephantopus scaber Linn. is a small perennial herb belongs to the
family Asteraceae found in tropical climates. The leaves and the roots
are used in treating diahorrea, liver disorders, tumors, inflammations
and ulcers. The phytochemical constituents of this plant indicate that it
contains sesquiterpene lactones, terpenoids, deoxyelephantopin etc.
Bioactivity guided fractionation of its acetone extract led to the
isolation and characterization of a novel flavanone, 8- hydroxyl
naringenin. The structure of the isolated compound A was elucidated
on the basis of NMR spectrum and mass spectrum as well as by
comparison with available data in the literature. The isolated
compound A showed inhibitory effect on all 12 tested bacteria like
Bacillus cereus, Salmonella typhi etc. Compound A, 8- hydroxyl
naringenin was active more than the crude acetone extract of E. scaber.
Keywords: Elephantopus scaber; flavanone; 8- hydroxyl naringenin; antibacterial activity; NMR.
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