A REVIEW ON ANALYTICAL METHODS FOR DETERMINATION OF DICYCLOMINE HYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORMS AND BIOLOGICAL SAMPLES
Malathi Raghunath*, Amol Arun Dhamne and Jyotsna Gajanan Patil
ABSTRACT
Dicyclomine Hydrochloride (DIC) is an antimuscarinic and
antispasmodic agent. DIC is used to treat a certain type of intestinal
problem called irritable bowel syndrome. It helps to reduce the
symptoms of stomach and intestinal cramping. Its action is achieved
via dual mechanisms; due to a specific anticholinergic effect at the
acetylcholine-receptor sites and a direct effect upon smooth muscle.
The drug is official in Indian Pharmacopoeia, United States
Pharmacopoeia and British Pharmacopoeia. Many analytical methods
have been reported for simultaneous estimation of DIC in its combined
pharmaceutical dosage form but only fewer methods have been
reported for estimation of DIC alone in pharmaceutical dosage forms.
DIC is an important active pharmaceutical ingredient used even in
children to relieve colic pain. This review therefore focuses on
analytical methods reported for the estimation of DIC in literature and any further scope of
developing novel instrumental analytical methods for estimation of DIC alone and in its fixed
dose combinations.
Keywords: DIC hydrochloride, Spectrophotometry, Chromatography, Potentiometry, Calorimetry, Antispasmodic.
[Full Text Article]