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Dr. Muhammad Baqir MR Fakhrildin
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Kinsuk Sarker, Debojyoti Basu and Prof. Dr. Dhrubo Jyoti Sen*


ABSTRACT: Pharmaceutical science deals with the drug and this drug is marketed in global range in the form of medicines for healthcare. Only the drug can bind with specific receptor to show desired biological action in-vivo whereas other chemical fails to show the same. All drugs are xenobiotics because it is coming from outer source (xeno) which is active in biological (biotics) system having less toxicity done by phase-I to phase-IV trials to pass the clinical aspects. Designing of lead molecule to most potent molecule and finally after crossing so many clinical trials this drug comes to the market in the form of some formulations incorporated with excipients. Paracetamol is para hydroxy acetanilide which is used as antipyretic because it binds at the receptor of heat regulating centre of cerebellum of brain but removing para hydroxy group it will become acetanilide which fails to bind at the same receptor to possess the biological activity. A specific drug can bind at specific receptor among huge receptors present in the body because its chemical structure fits at that specific receptor only and not for all receptors. No doubt that drug is definitely a chemical entity but all chemical entity never comes to the category of drug.

Keywords: xenobiotics, drug, API, excipients, medicine, receptor, druggist, FDA, enantiomers, clinical trials, therapeutic index, ion channels, lead molecule, potent molecule, biological action, toxicity

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