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Sanchit Srivastav, Dr. Md Akram Minhaj*, Manoj Kumar Prabhakar, Kanishk Luhach


The development of innovative compounds, pyrimidine hydrazones have been shown to possess a diverse variety of biological activities viz. antimicrobial, anticonvulsant, anti-oxidant, anti-inflammatory, analgesic, antimalaral, anticancer, antiviral, cardio protective etc., Pyrimidine constitutes an important class of heterocycles in drug discovery. Hydrazones is a class of organic compounds with the structure R1R2C=NNH2. They are formed usually by the action of hydrazine on ketones or aldehydes & have efficient CNS depressant, analgesics activity. In the same context, Schiff bases of pyrimidne hydrazones were prepared by the reaction of “4-(4-Chloro-phenyl)-6- methyl-2-oxo-1, 2, 3, 4-tetrahydro-pyrimidine-5-carboxylic acid hydrazideâ€Â with citral, camphor, furfuraldehyde & menthone individually by refluxing them in the presence of glacial acetic acid (as solvent) for at least 2hrs to yield their respective derivatives. The present studies revealed that Pyrimidine hydrazone derivatives could be used to synthesize the compounds having potent biological activities such as anticancer, antimicrobial, antioxidant, CNS depressant, analgesic & antiviral activities. All the prepared derivatives were under investigation for their antimicrobial activity and likely to posses the same & desired action.

Keywords: Pyrimidine Hydrazones, antimicrobial, antioxidant and Schiff Bases.

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