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Md. Arif uddin, Ariful Islam*, Md. Rakib Uddin, Jakia Sultana, Farjana Chowdhury, Rumana Ferdushi


In the present study, an effort has been made to evaluate of hydroxypropyl methylcellulose HPMC K4M as rate retardant polymer to sustain the release of Tramadol HCl from Tramadol HCl sustained release tablet matrix. Different amount of HPMC K4M were used by considering the factors such as moisture content, stability of ingredients, coating of tablets etc. in formulation of F1 to F5 where drug and polymer ratio were consequently 1:2, 5:9, 5:8, 5:7 and 5:6 in 200 mg tablet matrix . Tablets were prepared by direct compression. The dissolution study of the tablet matrices of different formulations were carried out in the gastric medium (pH 1.3) for first 2 hours and then in the intestinal medium (pH 6.8) for 6 hours using USP dissolution apparatus II. The drug release patterns were simulated in different kinetic orders such as Zero Order release kinetics, First Order release kinetics, Higuchi release kinetics, Korsemeyer-Peppas release kinetics and Hixson-Crowell release kinetics to assess the release mechanism. From the study it was observed that first Order release kinetics was the predominant release mechanism than Higuchi and zero Order kinetics. Among the formulations of F-1 to F-5, a different amount of HPMC K4M polymer can sustain the release of Tramadol HCl 62.33% to 100% in eight hour.

Keywords: Tramadol HCl, HPMC K4M, matrix tablet, first order plot, higuchi plot, zero order and dissolution studies.

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